GUaRDIAN is a consortium of over 100 clinicians and researchers from over 25 medical and research centers making it one of the largest clinical genomics research networks in India

What is GUaRDIAN ?
  GUaRDIAN is a collaborative research programme towards understanding the genetic basis and molecular mechanisms underlying rare genetic disorders. We use the advanced sequencing technologies, extensive bioinformatics and animal models. Our collaborators include a large number of clinicians and scientists.

Genomics for Precision Medicine in India
Our collaborative network includes pioneers in personal genome sequencing and analysis in India, and the collaborative network brings together the enormous expertise in clinical assessment, genome sequencing, analysis and interpretation. 

Focus areas of Research and Cohorts
Our network encompasses a wide variety of clinical specialties. Our large cohorts include Dermatology, Neurological disorders, Cardiovascular Diseases, Vascular Diseases, Immune Diseases, Opthalmological/Eye Diseases and Metabolic Diseases, just to name a few. We are open to include more cohorts in collaboration with clinical groups.  Please contact us for more details.

How can we help you
If you are a Clinician or Researcher, you could collaborate with the network and participate in ongoing research initiatives. Please contact us for more details

If you are a parent/caregiver to a child with rare genetic disease, you can contribute to GUaRDIAN by enrolling yourself in the Registry. 

Events and CME Update

  • Genomics for Clinicians / Tirunelveli Medical College Workshop on the concept and application of genomics in clinical medicine Genomic technologies have been progressing at break-neck speed in the recent years, with newer applications being developed almost ...
    Posted Apr 19, 2017, 11:00 PM by Vinod Scaria
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Recent Publications

  • Development of a Clinical Diagnostic Matrix for characterising Inherited Epidermolysis Bullosa. Accurately diagnosing the subtype of Epidermolysis Bullosa (EB) is critical for management and genetic counseling. Modern laboratory techniques are largely inaccessible in developing countries, where the diagnosis remains clinical and ...
    Posted May 1, 2017, 12:35 AM by Vinod Scaria
  • Unilateral monomorphic hypopigmented macules: A variant of Darier disease Darier disease, also known as keratosis follicularis, is an autosomal dominant genodermatosis that occurs as a result of mutation in the ATP2A2 gene, located on chromosome 12q23-24.1. It ...
    Posted Apr 29, 2017, 4:32 AM by Vinod Scaria
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Prasad Ravindranath in The Hindu (10th July 2016)
Jacob Koshy in The Hindu (12th May 2016)
Sridhar Sivasubbu & Vinod Scaria in LiveMINT (Feb 16 2016)
G N Prashanth in Deccan Herald (05th Jan 2015)


Books and Booklets

Pulse

  • Personal genomics in clinical medicine : it is not in the future anymore Vinod Scaria and Sridhar Sivasubbu. The decade following the International human genome sequencing initiative, which drew the blueprint of the human genome, has seen tremendous advancements that has made genomics ...
    Posted Mar 13, 2016, 3:11 AM by Vinod Scaria
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