GUaRDIAN is a consortium of over 100 clinicians and researchers from over 25 medical and research centers making it one of the largest clinical genomics research networks in India
What is GUaRDIAN ?
  GUaRDIAN is a collaborative research programme towards understanding the genetic basis and molecular mechanisms underlying rare genetic disorders. We use the advanced sequencing technologies, extensive bioinformatics and animal models. Our collaborators include a large number of clinicians and scientists.

Genomics for Precision Medicine in India
Our collaborative network includes pioneers in personal genome sequencing and analysis in India, and the collaborative network brings together the enormous expertise in clinical assessment, genome sequencing, analysis and interpretation. 

Focus areas of Research and Cohorts
Our network encompasses a wide variety of clinical specialties. Our large cohorts include Dermatology, Neurological disorders, Cardiovascular Diseases, Vascular Diseases, Immune Diseases and Metabolic Diseases, just to name a few. We are open to include more cohorts in collaboration with clinical groups.  Please contact us for more details.

How can we help you
If you are a Clinician or Researcher, you could collaborate with the network and participate in ongoing research initiatives. Please contact us for more details

If you are a parent/caregiver to a child with rare genetic disease, you can contribute to GUaRDIAN by enrolling yourself in the Registry. 

Pulse

  • Personal genomics in clinical medicine : it is not in the future anymore Vinod Scaria and Sridhar Sivasubbu. The decade following the International human genome sequencing initiative, which drew the blueprint of the human genome, has seen tremendous advancements that has made genomics ...
    Posted Mar 13, 2016, 3:11 AM by Vinod Scaria
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Recent Publications

  • Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation CHD7 mutations are implicated in a majority of cases of the congenital disorder, CHARGE syndrome. CHARGE, an autosomal dominant syndrome, is known to affect multiple tissues including eye, heart, ear ...
    Posted Jul 21, 2016, 4:47 AM by Vinod Scaria
  • Case Report: Whole exome sequencing reveals a novel frameshift deletion mutation p.G2254fs in COL7A1 associated with autosomal recessive dystrophic epidermolysis bullosa Dystrophic epidermolysis bullosa simplex (DEB) is a phenotypically diverse inherited skin fragility disorder. It is majorly manifested by appearance of epidermal bullae upon friction caused either by physical or environmental ...
    Posted Jun 27, 2016, 2:32 AM by Vinod Scaria
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In Media
Prasad Ravindranath in The Hindu (10th July 2016)
Jacob Koshy in The Hindu (12th May 2016)
Sridhar Sivasubbu & Vinod Scaria in LiveMINT (Feb 16 2016)
G N Prashanth in Deccan Herald (05th Jan 2015)
Books and Booklets

Events and CME Update

  • Genomics for Clinicians - Jaipur 2016 Workshop on the concept and application of genomics in clinical medicine Genomic technologies have been progressing at break-neck speed in the recent years, with newer applications being developed almost ...
    Posted Jul 20, 2016, 8:36 AM by Vinod Scaria
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http://www.genomes.in/