About Us

The GUaRDIAN project originated primarily as a research collaboration involving basic scientists and clinicians who got together to explore potential translational applications of genomic technologies. We have been motivated by the fact that currently a large number of diseases/traits have been shown to be associated with genetic variations in human. In this context India, which is a unique kettle of human genetic pool with high birth rate, restricted marriage practices including consanguinity and a poor availability of antenatal diagnostics is disposed to high frequencies of disease genotypes (Bittles et al., 2010). It is estimated that almost 64 of every 1000 live births in India carry a birth defect (Christianson et al., 2005); and 1 out of every 20 children are known to suffer from one or other form of genetic diseases in urban India (Ghosh and Rao 2005). With approximately 15.53 million babies born every year in India, the estimated fraction of Indian population suffering from genetic disorders assumes gigantic proportions. 

In this project, we hope to bring together the rich expertise of clinicans and basic science researchers towards both understanding novel genetic variations and their phenotypic correlates and also potentially suing this information and knowledge for translational applications.

Founders and Principal Investigators
Dr. Sridhar Sivasubbu
Co-founder and Investigator
Scientist, CSIR Institute of Genomics and Integrative Biology
Web: http://sridhar.rnabiology.org
Email: sridhar[at]igib.in


Dr. Vinod Scaria
Co-founder and Investigator
Scientist, CSIR Institute of Genomics and Integrative Biology
Web: http://vinodscaria.rnabiology.org
Email: vinods[at]igib.in




Funding
The activities of GUaRDIAN is funded through the following grants from Council of Scientific and Industrial Research, 
Grant BSC0212 (Wellness Genomics Project) and Grant BSC0122 (CARDiOMeD) , MLP1601 (GOMED), MLP1801 (RareGen) and MLP1802 (GOMED-Tech) for specific objectives pertaining to this project. Web: http://csir.res.in

Recently in Media

  • IMHANS to have new genetic research facility Diagnosis of genetic disorders among children, and detailed research into them will soon be made possible at the Kozhikode-based Institute of Mental Health and Neuroscience (IMHANS).The institute is ...
    Posted Oct 3, 2018, 2:33 AM by Vinod Scaria
  • IGIB researchers partially reverse a rare disorder Researchers at Delhi’s Institute of Genomics & Integrative Biology (CSIR-IGIB) have for the first time used zebra fish to model the rare genetic disorder — Rubinstein Taybi Syndrome (RSTS) — seen ...
    Posted Jul 18, 2018, 11:58 PM by Vinod Scaria
  • 5-year-old ‘butterfly’ boy at PGI for treatment By Shimona Kanwar CHANDIGARH: A five-year-old suffering from dystrophic Epidermolysis Bullosa (EB), a painful and rare genetic skin disease, is being treated in PGI. Kids with EB are ...
    Posted Apr 13, 2018, 10:38 PM by Vinod Scaria
  • An anomaly that could kill - AS Jayanth in The Hindu Primary immune deficiency disorder could spark prolonged or frequent illness among children“It is quite normal for a child to develop upper respiratory infections if he or she is exposed ...
    Posted Jul 25, 2017, 8:21 PM by Vinod Scaria
  • Interpretation of a malady: how scientists zeroed in on one family's rare and crippling disease The poignant story of an Agra family, where six children have the Nalband mutation. Reports on how a group of scientists linked it to a rare and crippling neurological disease ...
    Posted Jun 7, 2017, 11:21 PM by Vinod Scaria
Showing posts 1 - 5 of 11. View more »

Rare Disease India Alliance

https://www.facebook.com/RareDiseaseIndia
Rare Disease India is a virtual organisation connecting patients, caregivers, doctors and researchers working in the are of Rare Genetic Diseases in India
Subpages (1): Background