About Us

The GUaRDIAN project originated primarily as a research collaboration involving basic scientists and clinicians who got together to explore potential translational applications of genomic technologies. We have been motivated by the fact that currently a large number of diseases/traits have been shown to be associated with genetic variations in human. In this context India, which is a unique kettle of human genetic pool with high birth rate, restricted marriage practices including consanguinity and a poor availability of antenatal diagnostics is disposed to high frequencies of disease genotypes (Bittles et al., 2010). It is estimated that almost 64 of every 1000 live births in India carry a birth defect (Christianson et al., 2005); and 1 out of every 20 children are known to suffer from one or other form of genetic diseases in urban India (Ghosh and Rao 2005). With approximately 15.53 million babies born every year in India, the estimated fraction of Indian population suffering from genetic disorders assumes gigantic proportions. 

In this project, we hope to bring together the rich expertise of clinicans and basic science researchers towards both understanding novel genetic variations and their phenotypic correlates and also potentially suing this information and knowledge for translational applications.

Founders and Principal Investigators

Dr. Sridhar Sivasubbu
Co-founder and Investigator
Scientist, CSIR Institute of Genomics and Integrative Biology
Web: http://sridhar.rnabiology.org
Email: sridhar[at]igib.in

Dr. Vinod Scaria
Co-founder and Investigator
Scientist, CSIR Institute of Genomics and Integrative Biology
Web: http://vinodscaria.rnabiology.org
Email: vinods[at]igib.in

The activities of GUaRDIAN is funded through the following grants from Council of Scientific and Industrial Research, 
Grant BSC0212 (Wellness Genomics Project) and Grant BSC0122 (CARDiOMeD) , MLP1601 (GOMED), MLP1801 (RareGen) and MLP1802 (GOMED-Tech) for specific objectives pertaining to this project. Web: http://csir.res.in

Recently in Media

  • Genome sequencing by CSIR to help in Precision Medicine in India The Council for Scientific and Industrial Research has sequenced the entire genomes of 1008 Indians in six months, under a mission that was aimed at demonstrating capability and scalability of ...
    Posted Oct 31, 2019, 12:33 AM by Vinod Scaria
  • Workshop on Genomics in Clinical Medicine at Aster Medcity, Kochi A workshop on Genomics in Clinical Medicine was held at Aster Medcity. This workshop was conducted by researchers at the CSIR Institute of Genomics and Integrative Biology(CSIR IGIB), one ...
    Posted Jan 31, 2019, 1:12 AM by Vinod Scaria
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    Posted Oct 3, 2018, 2:33 AM by Vinod Scaria
  • IGIB researchers partially reverse a rare disorder Researchers at Delhi’s Institute of Genomics & Integrative Biology (CSIR-IGIB) have for the first time used zebra fish to model the rare genetic disorder — Rubinstein Taybi Syndrome (RSTS) — seen ...
    Posted Jul 18, 2018, 11:58 PM by Vinod Scaria
  • 5-year-old ‘butterfly’ boy at PGI for treatment By Shimona Kanwar CHANDIGARH: A five-year-old suffering from dystrophic Epidermolysis Bullosa (EB), a painful and rare genetic skin disease, is being treated in PGI. Kids with EB are ...
    Posted Apr 13, 2018, 10:38 PM by Vinod Scaria
Showing posts 1 - 5 of 13. View more »

Rare Disease India Alliance

Rare Disease India is a virtual organisation connecting patients, caregivers, doctors and researchers working in the are of Rare Genetic Diseases in India
Subpages (1): Background