Currently more than 7000 diseases are associated with genetic mutations in human. This assumes a significant portion of disease burden of even in developing nation. In this context India, which is a unique kettle of human genetic pool with high birth rate, restricted marriage practices including consanguinity and a poor availability of antenatal diagnostics is disposed to high frequencies of disease genotypes (Bittles et al., 2010). It is estimated that almost 64 of every 1000 live births in India carry a birth defect (Christianson et al., 2005); and 1 out of every 20 children are known to suffer from one or other form of genetic diseases in urban India (Ghosh and Rao 2005). With approximately 15.53 million babies born every year in India, the estimated fraction of Indian population suffering from genetic disorders assumes gigantic proportions. The scale of the problem is highlighted from the fact that the number of children suffering from genetic disorders in India is higher than the total population of some of the small countries like Norway.
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