GUaRDIAN is a consortium of over 100 clinicians and researchers from over 25 medical and research centers making it one of the largest clinical genomics research networks in India

What is GUaRDIAN ?
  GUaRDIAN is a collaborative research programme towards understanding the genetic basis and molecular mechanisms underlying rare genetic disorders. We use the advanced sequencing technologies, extensive bioinformatics and animal models. Our collaborators include a large number of clinicians and scientists.

Genomics for Precision Medicine in India
Our collaborative network includes pioneers in personal genome sequencing and analysis in India, and the collaborative network brings together the enormous expertise in clinical assessment, genome sequencing, analysis and interpretation. 

Focus areas of Research and Cohorts
Our network encompasses a wide variety of clinical specialties. Our large cohorts include Dermatology, Neurological disorders, Cardiovascular Diseases, Vascular Diseases, Immune Diseases, Opthalmological/Eye Diseases and Metabolic Diseases, just to name a few. We are open to include more cohorts in collaboration with clinical groups.  Please contact us for more details.

How can we help you
If you are a Clinician or Researcher, you could collaborate with the network and participate in ongoing research initiatives. Please contact us for more details

If you are a parent/caregiver to a child with rare genetic disease, you can contribute to GUaRDIAN by enrolling yourself in the Registry. 

Events and CME Update

  • GenoDerma (03-05 Feb 2017, Pune) - Genomics in Clinical Dermatology The Conference on Genomics in Clinical DermatologyThe cost of sequencing a genome is falling exponentially, putting vast amount of data in the hand of clinicians and researchers. This conference ...
    Posted Oct 11, 2016, 6:18 AM by Vinod Scaria
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Recent Publications

  • Elucidating the Phenotype and Genotype Spectrum of Junctional Epidermolysis Bullosa in India HighlightsJunctional epidermolysis bullosa (JEB) is a clinically and genetically heterogenous group of genetic skin disorders.•We show the utility of WES in understanding the phenotype and genotype spectrum in ...
    Posted Feb 21, 2017, 7:52 AM by Vinod Scaria
  • Egyptian tale from India: application of whole-exome sequencing in diagnosis of atypical familial Mediterranean fever Autoinflammatory diseases encompass a spectrum of diseases characterized by dysfunction of the innate immune system. Until recently, these diseases were largely classified and diagnosed by the clinical presentation. The recent ...
    Posted Feb 21, 2017, 7:48 AM by Vinod Scaria
  • Rescue of neural crest derived phenotypes in a zebrafish CHARGE model by sox10 downregulation CHD7 mutations are implicated in a majority of cases of the congenital disorder, CHARGE syndrome. CHARGE, an autosomal dominant syndrome, is known to affect multiple tissues including eye, heart, ear ...
    Posted Jul 21, 2016, 4:47 AM by Vinod Scaria
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Prasad Ravindranath in The Hindu (10th July 2016)
Jacob Koshy in The Hindu (12th May 2016)
Sridhar Sivasubbu & Vinod Scaria in LiveMINT (Feb 16 2016)
G N Prashanth in Deccan Herald (05th Jan 2015)


Books and Booklets

Pulse

  • Personal genomics in clinical medicine : it is not in the future anymore Vinod Scaria and Sridhar Sivasubbu. The decade following the International human genome sequencing initiative, which drew the blueprint of the human genome, has seen tremendous advancements that has made genomics ...
    Posted Mar 13, 2016, 3:11 AM by Vinod Scaria
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