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IGIB researchers partially reverse a rare disorder

posted Jul 18, 2018, 11:57 PM by Vinod Scaria   [ updated Jul 18, 2018, 11:58 PM ]
Researchers at Delhi’s Institute of Genomics & Integrative Biology (CSIR-IGIB) have for the first time used zebra fish to model the rare genetic disorder — Rubinstein Taybi Syndrome (RSTS) — seen in humans. They have also used two small molecules to partially reverse some of the defects caused by the disorder in zebrafish, thus showing them to be an ideal animal model for screening drug candidates. There is currently no cure or treatment for the disorder.

"The syndrome also affects about one in one lakh people, causing a range of defects"

The Rubinstein Taybi Syndrome has a frequency of about one in one lakh people, and causes intellectual disability, growth retardation (short stature), craniofacial deformities, heart defects and broad thumbs and toes. The results were published in the journal Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.


From Chetana Sachidanandan Lab at CSIR-Institute of Genomics and Integrative Biology

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