Primary Immunodeficiency Disorders

The GUaRDIAN Programme on Primary Immunodeficiency Disorders is a collaborative initiative to provide holistic approach to patient care including genomic diagnosis, management and prevention of Primary Immunodeficiency Disorders. Spotlight on Primary Immune Deficiency Disorders Handbook for Clinicians (1st Edition 2019) Primary Immunodeficiency Disorders  Handbook for Patients & Families English | Malayalam Printable Poster on Primary Immunodeficiency Printable poster for your clinic / educational activities Blog More about Primary Immunodeficiency at the GUaRDIAN GenomeConnect Blog

GUaRDIAN Network Centres Collaborative Programme on Pediatric  Immune Disorders Govt. Medical College Kozhikode, KERALA Delhi/NCR Initiative for Primary Immunodeficiency Disorders Maulana Azad Medical College, DELHI St Stephen's Hospital, DELHI Super Specialty Pediatric Hospital and Postgraduate Teaching Institute NOIDA All India Institute of Medical Sciences, DELHI Gujarat Initiative for Primary Immunodeficiency Disorders Maharashtra Initiative for Primary Immunodeficiency Disorders Dr. DY Patil Medical College Hospital and Research Centre, PUNE  Educational Programmes Seminars in Pediatric Immunology 2020  November and December 2020 Online Update on Primary Immunodeficiency Disorders  Sunday, August 18, 2019, Govt. Medical College, Kozhikode, KERALA In News Genome sequencing: A solution to India's problem of rare genetic diseases Economic Times NOV 02, 2019 Diagnostic centre for primary immune deficiency disorders The Hindu MARCH 25, 2019

Publications Govindaraj GM, Krishnakumar P, Scaria V, Athulya E, Ajithkumar VT, Dongre AR. Building on an Ad Hoc Covid-19 Response to Enhance Community-based Care for Vulnerable Children in Kerala, India.  NEJM Catal Innov Care Deliv. (2020) doi: 10.1056/CAT.20.0543. Govindaraj GM, Ramya U, Raj R, Athulya EP, Jain A, Scaria V, Jayakrishnan MP, Sivasubbu S, Dhanasooraj D, Ajithkumar VT, Dongre AR, Krishnakumar P. Parental Experience of Hematopoietic Stem Cell Transplantation for Children with Primary Immune Deficiency Disorders. Indian J Pediatr. (2020) Oct 23. doi: 10.1007/s12098-020-03541-3. Online ahead of print. Govindaraj GM, Jain A, Peethambaran G, Bhoyar R, Vellarikkal SK, Ganapati A, Sandhya P, Edavazhippurath A, Dhanasooraj D, Puthenpurayil JM, Chakkiyar K, Mishra A, Batra A, Punnen A, Kumar S, Sivasubbu S, Scaria V Spectrum of clinical features and genetic variants in mevalonate kinase (MVK) gene of South Indian families suffering from Hyperimmunoglobulin D Syndrome  PLoS ONE (2020) https://doi.org/10.1371/journal.pone.0237999 Sharma P, Jain A, Scaria V Genetic landscape of rare autoinflammatory disease variants in Qatar and Middle Eastern populations through the integration of genomic datasets medRxiv (2020) .08.10.20171363;  [This is a preprint and presently under peer review] Koshy R, Sivadas A, Scaria V. Genetic epidemiology of Familial Mediterranean Fever through integrative analysis of whole genome and exome sequences from Middle East and North Africa Clinical Genetics (2017) Jan;93(1):92-102. doi: 10.1111/cge.13070 Sandhya P, Vellarikkal SK, Nair A, Ravi R, Mathew J, Jayarajan R, Kumar A, Verma A, Sivadas A, Danda D, Sivasubbu S*, Scaria V* An Egyptian tale from India - application of whole-exome sequencing in diagnosis of atypical Familial Mediterranean Fever Int J Rheum Dis (2017) Nov;20(11):1770-1775. doi: 10.1111/1756-185X.13042. Govindaraj GM, Karuthedath Vellarikkal S, Jayarajan R, Ravi R, Verma A, Chakkiyar K, Jayakrishnan MP, Arakkal R, Raj R, Kunnaruvath R, Sivasubbu S, Scaria V Case Report: Whole exome sequencing identifies variation c.2308G>A p.E770K in RAG1 associated with B- T- NK+ severe combined immunodeficiency F1000Research 2017, 5:2532 Govindaraj GM, Riyaz A, Krishnan C, Scaria V. Rapid Transition of Facial Features from Early to Mid - Adolescence in Autosomal Dominant Hyper IgE Syndrome with a STAT3 Variation. Indian J Pediatr. 2018 Jul;85(7):595-596.