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ThalAId Thalassemia Associated Iron Overload

Thalassemia is affects thousands of Indians and it is estimated that nearly 10,000 new patients are born every year. Multiple mutations in the globin genes, lead to globin synthesis imbalance, resulting in Thalassemia. The average prevalence of the homozygous state across the country ranges from 3-4% with certain communities recording as high as 80% homozygosity/trans-heterozygosity. The genetic diversity of the Indian population means that around 28 of the 200 known mutations responsible for Thalassemia is present in India.

Patients of Thalassemia Major require regular blood transfusions. This helps the anemia that patients suffer but it also leads to iron overload. Iron overload affects multiple tissues such as liver, heart, spleen, pancreas, thyroid etc. bringing more suffering to the patients. However, there are also patients who are refractory to Iron overload in spite of regular transfusions. This suggests that there are other genes in the patient genome which determine whether they develop iron overload or not. A knowledge of these other genes can help predict the response of the patient to transfusion.

This project aims to indentify and understand the role of genetic modifiers that affect the iron status in the Thalassemia patients.

We invite you and your Department/Institute to be part of this ongoing collaborative effort.
 Contact Dr. Chetana

Principal Investigators
Dr. Chetana Sachidanandan / CSIR-IGIB, Delhi

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Referral Process
As part of the collaborative initiative, we aim to study Thalassemia assocaited Iron Overload. Please contact us for more details.

We have a standardized referral and consenting process which is detailed online at at

GUaRDIAN : Intergrating Personalised and Precision Medicine

CSIR Institute of Genomics and Integrative Biology (CSIR-IGIB) New Delhi has initiated a unique programme on this front, pioneering the application of genomics for Precision Medicine in clinics in India.

One of the programmes we have initiated is Genomics for Understanding Rare Disease, India Alliance Network (GUaRDIAN), which is a large-scale collaborative network of clinicians from around India trying to integrate genomics in clinical practice, with the a singular focus to elucidate the genetic structure of rare genetic diseases in India.